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Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 ...

28 Nov 2013 ... Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells. V A Mitkevich, I Y Petrushanko, [...], and S A ...

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Signaling Effect of Amyloid-β42 on the Processing of AβPP ...

Request PDF | Signaling Effect of Amyloid-β42 on the Processing of AβPP | The effects of amyloid-beta are extremely complex. Current work in the field of ...

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Functional and molecular characterization of the effect of amyloid ...

J Alzheimers Dis. 2014;38(4):787-98. doi: 10.3233/JAD-122374. Functional and molecular characterization of the effect of amyloid-β42 on an in vitro epithelial ...

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(PDF) Different effects of soluble and aggregated amyloid β42 on ...

28 Oct 2019 ... Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways.

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Beyond the signaling effect role of amyloid-β42 on the processing of ...

Alzheimer's disease (AD) currently has over 6 million victims in the USA, alone. The recently FDA approved drugs for AD only provide mild, transient relief for ...

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Distinct spatiotemporal accumulation of N-truncated and full-length ...

17 Nov 2019 ... We observed that N-terminally truncated amyloid-β42 and full-length amyloid-β 42 accumulations distributed differently across disease stages ...

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Vishnyakova ks - Google Scholar Citations

Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells. Cell.death.disease.2013 (4) e939. V Mitkevich, YI Petrushanko, ...

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(PDF) Functional and Molecular Characterization of the Effect of ...

Functional and Molecular Characterization of the Effect of Amyloid-β42 on an in vitro Epithelial Barrier Model. Article (PDF Available) in Journal of Alzheimer's ...

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Signaling effect of amyloid-β42 on the processing of AβPP ...

The effects of amyloid-β are extremely complex. Current work in the field of Alzheimer disease is focusing on discerning the impact between the physiological ...

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Different effects of soluble and aggregated amyloid β42 on gene ...

11 Jul 2012 ... Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways.

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Signaling Effect of Amyloid-β42 on the Processing of AβPP - Europe ...

9 Sep 2009 ... FULL TEXT Abstract: The effects of amyloid-beta are extremely complex. Current work in the field of Alzheimer disease is focusing on ...

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Cerebrospinal fluid TAU protein and amyloid β42 in mild cognitive ...

Cerebrospinal fluid (CSF) TAU protein and Amyloid β42 were able to distinguish between 28 mild cognitive impairment (MCI) patients and both 38 normal aged ...

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Evaluation of Neurotoxicity of Alzheimer's Amyloid β Protein (β42) in ...

Neurotoxicity of β42(20μM) in cultured rat hippocampal neurons was evaluated by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) ...

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Plasma levels of insulin and amyloid β42 are correlated in patients ...

5 Dec 2005 ... Keywords: Amyloid β42, insulin, Alzheimer's disease, type 2 diabetes, ... is able to produce accumulation of insulin and amyloid β42 (Aβ42), the ...

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Platelet-activating factor antagonists enhance intracellular ...

13 Mar 2014 ... Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases.

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Distinct spatiotemporal accumulation of N-truncated and full-length ...

1 Dec 2019 ... Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease. Mitsuru Shinohara, Shunsuke Koga, ...

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Possible Biomarker for Preclinical AD Found | MDedge Internal ...

1 Sep 2006 ... This decline of Aβ42 in cerebrospinal fluid appears to begin in early adulthood and to rapidly accelerate between the ages of 50 and 60 years ...

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Alexandra Kulikova - Google Scholar Citations

Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells. VA Mitkevich, IY Petrushanko, YE Yegorov, OV Simonenko, .

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Transgenic Drosophila melanogaster expressing a β42 in the eye ...

31 May 2005 ... Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of ...

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APOE genotype results in differential effects on the peripheral ...

APOE genotype results in differential effects on the peripheral clearance of amyloid-β42 in APOE knock-in and knock-out mice. Matthew J. Sharman, Michael ...

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Molecular Simulations Reveal Terminal Group Mediated ...

27 Mar 2019 ... The presence of partially structured helices in natively unfolded amyloid-β42 ( Aβ42) and α-synuclein (αS) has been shown to accelerate ...

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Proliferation of amyloid-β42 aggregates occurs through a secondary ...

11 Jun 2013 ... Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Samuel I. A. Cohen, Sara Linse, Leila M. Luheshi, ...

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The effects of aging on Amyloid-β42

Alzheimer disease is the most prevalent neurodegenerative disease and is associated with aggregation of Amyloid-β42 peptides. In mammals, Amyloid-β42  ...

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Orkid Coskuner Weber (0000-0002-0772-9350) - ORCID ...

Revisiting Cu(II) Bound Amyloid-β40 and Amyloid-β42 Peptides: Varying Coordination ChemistriesJournal of the Turkish Chemical Society, Section A: ...

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Anti-Amyloid β42 Antibody, clone G2-13 | Sigma-Aldrich

Anti-Amyloid β42 Antibody, clone G2-13; Synonym: Alzheimer disease, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Protease nexin-II ...

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SH2B1 is involved in the accumulation of amyloid-β42 in ...

SH2B1 is involved in the accumulation of amyloid-β42 in Alzheimer's disease. Manuscript Number: 16-0233R2. Author(s):. Fude Huang, Nastasia K-H Lim, ...

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High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the ...

High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype.

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Soluble Amyloid-β42 Peptides Regulate Gene Transcription

18 Jul 2014 ... Soluble amyloid-β42 peptides eventually precipitate to form insoluble plaques that are a characteristic formation in the brains of Alzheimer ...

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Blood-brain barrier-associated pericytes internalize and clear ...

19 Oct 2019 ... Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific ...

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Amyloid β42 peptide is toxic to non-neural cells in Drosophila ...

Amyloid β42 peptide is toxic to non-neural cells in Drosophila yielding a characteristic metabolite profile and the effect can be suppressed by PI3K. Mercedes ...

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γ-Secretase modulators reduce endogenous amyloid β42 levels in ...

22 Apr 2019 ... γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation.

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Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in ...

12 Jun 2013 ... Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in Presenilin Mutation Carriers. Rachel Potter,*,; Bruce W. Patterson,*,; Donald ...

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siRNA against presenilin 1 (PS1) down regulates amyloid β42 ...

3 Jan 2012 ... One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid β protein (Aβ) within lesions known as ...

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Decreased CSF amyloid β42 and normal tau levels in dementia with ...

27 Feb 2001 ... To the Editor: We read with interest the article by Kanemaru et al.1 on the levels of CSF amyloid β42 and tau in patients with dementia with ...

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The Effect of Changing the Amyloid β42 Cut-off of Cerebrospi ...

The Effect of Changing the Amyloid β 42 Cut-off of Cerebrospinal Fluid Biomarkers on Alzheimer Disease Diagnosis in a Memory Clinic Population in Norway.

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Human Amyloid β42 Brain ELISA | EZBRAIN42

This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research. - Find MSDS or SDS, a COA, data sheets ...

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High Sensitivity Human Amyloid β42 ELISA | EZHS42

This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research. - Find MSDS or SDS, a COA, data  ...

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Computational design and evaluation of β‐sheet breaker peptides ...

4 Jun 2019 ... Computational design and evaluation of β‐sheet breaker peptides for destabilizing Alzheimer's amyloid‐β42 protofibrils. Suniba Shuaib.

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Correction: Abnormal CSF amyloid-β42 and tau levels in hip fracture ...

26 Oct 2019 ... Notice of republication. This article was republished on October 16, 2019 to correct for formatting errors in the Materials and methods, Results, ...

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Hemoglobin Louisville (β42 (CD1) Phe→Leu): an unstable ... - JCI

Hemoglobin Louisville (β42 (CD1) Phe→Leu): an unstable variant causing mild hemolytic anemia · Marie M. Keeling, … , Janice L. Kitchens, T. H. J. Huisman.

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